生物质转化研究团队

赵宗保，教授，博士生导师。国家杰出青年科学基金获得者，国务院政府特殊津贴专家，辽宁省“兴辽英才计划”科技创新领军人才，中国化学会高级会员，中国化工学会生物化工专委会副主任委员，辽宁省可再生能源学会副会长，学术期刊《FEMS Yeast Research》和《Bioresources and Bioprocessing》编辑。主要从事生物转化技术、合成生物技术和化学生物学研究，代表性研究内容包括：微生物油脂技术及生物质炼制、产油酵母系统生物学及其工程化改造、非天然辅酶及能量代谢工程等。已在Nature, Nat. Chem. Biol., Nat. Commun., J. Am. Chem. Soc.和Bioresour. Technol.等学术刊物上发表论文280余篇，授权发明专利60余件。曾获辽宁省自然科学二等奖（2021、2018、2017）、大连市技术发明一等奖（2018、2013）和中国药学会科学技术一等奖（2015）等学术奖项。曾获中国科学院“引进国外杰出人才”、辽宁省“优秀科技工作者”、辽宁省学术头雁、中国可再生能源学会“优秀科技工作者”、中国科学院“朱李月华”优秀教师和大连市劳动模范等荣誉。

工作及教育经历

2023.10— 大连理工大学，生物工程学院，教授，博士生导师

2015.04—2023.10，中国科学院大连化学物理研究所，生物技术研究部，研究员，副主任，博士生导师

2003.11—2023.10，中国科学院大连化学物理研究所，生物技术研究部，研究员，博士生导师

2001.03—2003.10，美国德克萨斯大学奧斯汀校区，药学院，博士后/研究助理

1998.08—2001.02，美国明尼苏达大学，化学系，博士后

1995.09—1998.07，中国科学院上海有机化学研究所，天然有机研究室，博士生

1992.09—1995.08，湖南师范大学，化学系，硕士生

1986.09—1990.07，湖南师范大学，化学系，本科生

代表性文章

Li Q, Guo XJ, Wang XY, Wang JT, Wan L, Xue HZ, Zhao ZK*. “Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation” J. Energy Chem. 2023, 79, 31–36. View Full Text
Huang QT#, Kamal R#, Shen HW, Lu HB, Song JY, Chu YD, Xue C*, Zhao ZK*. “Pilot-scale conversion of corn stover into lipids by the red yeast Rhodosporidium toruloides” J. Environ. Chem. Eng. 2022, 10, 108858. View Full Text
Wang XY, Feng YB, Guo XJ, Wang Q, Ning SY, Li Q, Wang JT, Wang L, Zhao ZK*. “Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide” Nat. Commun. 2021, 12(1), 2116. View Full Text
Guo XJ, Liu YX, Wang Q, Wang XY, Li Q, Liu WJ, Zhao ZK*. “Non-natural cofactor and formate-driven reductive carboxylation of pyruvate” Angew. Chem. Int. Ed. 2020, 59(8), 3143–3146.　　View Full Text
Liu YX, Feng YB, Wang L, Guo XJ, Liu WJ, Li Q, Wang XY, Xue S*, Zhao ZK*. “Structural insights into phosphite dehydrogenase variants favoring a non-natural redox cofactor” ACS Catal. 2019, 9(3), 1883–1887.　　View Full Text
Wang YN, Zhang SF*, Zhu ZW, Shen HW, Lin XP, Jin X, Jiao X, Zhao ZK*. “Systems analysis of phosphate-limitation induced lipid accumulation by the oleaginous yeast Rhodosporidium toruloides” Biotechnol. Biofuels 2018, 11, 148.　　View Full Text
Zhu ZW, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK*, Nielsen J*. “Expanding the product portfolio of fungal type I fatty acid synthases” Nat. Chem. Biol. 2017, 13(4), 360–362.　　View Full Text
Wang L, Ji DB, Liu YX, Wang Q, Wang XY, Zhou YJ, Zhang YX, Liu WJ*, Zhao ZK*. “Synthetic cofactor-linked metabolic circuits for selective energy transfer” ACS Catal. 2017, 7(3), 1977–1983.　　View Full Text
Gong ZW, Shen HW, Yang XB, Wang Q, Xie HB, Zhao ZK*. “Lipid production from corn stover by the oleaginous yeast Cryptococcus curvatus” Biotechnol. Biofuels 2014, 7, 158.　　View Full Text
Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang YJ, Zhang XN, Liu WJ, Peters RJ*, Chen XY, Zhao ZK*, Huang LQ*. “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts” Proc. Natl. Acad. Sci. USA 2013, 110(29), 12108–12113.　　View Full Text
Zhu ZW, Zhang SF, Liu HW, Shen HW, Lin XP, Yang F, Zhou YJ, Jin GJ, Ye ML, Zou HF*, Zhao ZK*. “A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides” Nat. Commun. 2012, 3, 1112.　　View Full Text
Zhou YJ, Gao W, Rong QX, Jin GJ, Chu HY, Liu WJ, Yang W, Zhu ZW, Li GH, Zhu GF, Huang LQ*, Zhao ZK*. “Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production” J. Am. Chem. Soc. 2012, 134(6), 3234–3241.　　View Full Text
Ji DB, Wang L, Hou SH, Liu WJ, Wang JX, Wang Q, Zhao ZK*. “Creation of bioorthogonal redox systems depending on nicotinamide flucytosine dinucleotide” J. Am. Chem. Soc. 2011, 133(51), 20857–20862.　　View Full Text

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